Chiral Recognition and Separation Mechanisms:
Grinberg, Nelu |
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ISBN 13: 9781439852576 ISBN 10: 143985257X Category: Pharmacy Edition: 1 Publisher: Taylor & Francis Publication Date: 05/2025 Format: Cloth Status: Not Yet Published Imprint: CRC Press Affiliation: Boehringer-Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA Pages: 350 Weight: 1 Retail Price: 199.95 (Tentative Price May Change) Quantity On Hand: 0 Quantity On Order: 0 |
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Synopsis: Chirality plays a major role in biological processes and the enantiomers of a bioactive molecule often possess different biological effects. Accurate assessment is critical as isomeric impurities may have unwanted toxicological, pharmacological, or other effects. Separation techniques remain the method of choice for this area of drug research but there is a great deal of trial and error in choosing a particular column for a chiral separation. This book gives a rationale for choosing a stationary phase that is based on the relationship that exists between the analytes and the chiral stationary phases. The text provides examples to underline the separation mechanism. |
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