Multifaceted Role of IL-1 in Cancer and Inflammation summarizes the existing literature and discusses future perspectives about the role of IL-1 in immune suppression, cancer progression, angiogenesis, and resistance to immunotherapies. The book presents mechanisms to overcome IL-1 mediated immune suppression in tumor microenvironment and covers topics on the source of IL-1 in the tumor microenvironment, IL-1 mediated downstream pathway, mechanism of IL-1 mediated immune suppression in cancer, and its effect on immunotherapy of cancer. Those topics help readers understand the effect of IL-1 on cancer immunopathology and immunotherapy, and provide them with broader concepts to develop therapies for IL-1 enrichment tumors.

This is a valuable source for cancer researchers, clinicians and other members of the biomedical field who wants to learn more about mechanisms to improve outcome of cancer immunotherapies.

• Presents a summary in the beginning of each chapter to help readers to find the needed information and understand the content easily
• Encompasses detailed schematic diagrams and illustrations throughout the content to explain the complex immune mechanisms discussed
• Discusses future perspectives in all chapters to motivate researchers to work on emerging problems
• Includes contributions from internationally renown experts sharing their experiences on clinics and research