This book presents a hands-on tutorial on how to analyze patient-reported outcomes (PROs) in clinical research. PROs research often involves asking patients to fill out surveys to report their symptoms (e.g., how often, how severe, and how bothersome) or other outcomes that are important to the patients' clinical management. PROs data analysis involves statistical design considerations and data analytics for the development and testing of new surveys, the scoring of survey responses, and the calculation of clinically important cutoff scores.