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Book Detail
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Addiction, Second Edition
Pierce, R. Christopher
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Previous ISBN (13): 9781936113477 Publisher: Oxford University Press Imprint: Cold Spring Harbor Laboratory Press Affiliation: Rutgers University Robert Wood Johnson Medical School Audience: Professional and scholarly Dimensions: 7.2 x 0.9 x 10.1 in
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Synopsis:
Addiction to psychoactive drugs found in cigarettes, alcoholic drinks, and opioid analgesics is a severe problem for society. Events associated with addiction-drug abuse, dependence, withdrawal, and relapse-involve complex neurobiological changes in the brain. To develop effective long-term
treatment strategies for substance use disorders, a more complete understanding of these brain changes is needed.
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive update on our understanding of the biological basis of and treatment strategies for addiction to psychoactive drugs, with an emphasis on opioids. Contributors examine
the molecular targets of alcohol, cannabinoids, nicotine, stimulants, and opioids, the resulting changes to the neurocircuitry, and various genetic, environmental, developmental, and behavioral factors that influence the progression from abuse to addiction and susceptibility to relapse. Advances in
animal models of addictive behavior and single-cell strategies to dissect neural circuits are also described.
In addition, the authors review compounds currently used or under development to treat substance use disorders, their pharmacological mechanisms, and challenges related to preclinical testing in animal models. This volume is an indispensable reference for all neuroscientists and those who are
interested in understanding and reducing the public health burden of drug addiction.
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